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  • Optimized for Herecenones and Erinacines, the bioactive compounds researched for its ability to stimulate nerve growth factor (NGF) synthesis.
  • Contains the highest levels of polysaccharides, beta-glucans and polyphenols than any other Lion's Mane mushroom product.
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LEARN MORE ABOUT QI TRADITIONS LION'S MANE

You won’t find more potent Lion’s Mane anywhere. Scientifically verified for the highest concentration of active ingredients per gram.

And we have the tests to prove it.

Optimized
Optimized for Erinacines and Herecenones that stimulate NGF synthesis.

Tested
Rigorously tested for active ingredients,
heavy metals, pesticides, microbiology.

Verified
Non-GMO Project Verified and traceable from spore to finished product.

ABOUT "NATURE'S NATURAL DYNAMO"

Lion’s Mane (aka Hericium erinaceus, Monkey's Head, Houtou, Igelstachelbart, Pom Pom Blanc, Hedgehog Mushroom, Satyr’s Beard) pulls no punches on why it deserves its famous name. Here’s a safe and edible mushroom that promotes good digestion, general vigour and strength. It aids the central nervous system and helps with insomnia, vacuity (weakness) and hypodynamia, which are characteristic symptoms of Qi deficiency in Traditional Chinese medicine (TCM).

Also known as Hericium erinaceus, Lion’s Mane plays a role in sustaining the five internal organs (liver, lung, spleen, heart, and kidney). This remarkable natural restorative has a long and successful history in Chinese and Japanese medicine as an aid in fortifying the spleen, nourishing the gut, and guarding against chronic gastritis and ulcers.

Lion’s Mane derives its reputation for enhancing and prolonging mental functions such as memory and general cognition from its rich supplies of helpful bioactive compounds (including β-glucan polysaccharides, hericenones and erinacine terpenoids, isoindolinones, sterols and myconutrients). These active ingredients are sought after for their neuroprotective and neuroregenerative properties because they help to stimulate the synthesis of the Nerve Growth Factor (NGF) protein.

USES AND PURPOSES

  • Stimulates production of nerve growth factor (NGF)
  • Improves cognitive function
  • Eliminates brain fog
  • Relieves symptoms of anxiety and depression
  • Reduces inflammation
lion's mane herb benefits

HEALTH CANADA GUIDANCE AND RECOMMENDATIONS

Uses or purposes

  • Source of /Provides antioxidants.
  • Source of /Provides antioxidants that help fight/protect (cell) against/reduce (the oxidative effects of/the oxidative damage caused by/cell damage caused by) free radicals.

Dose and quantities

Adults 18 years and older.

Not to exceed 2.8 g of dried cultured mycelium/fruiting body/mycelium per day.

Cautions and Warnings

Consult a health care practitioner/health care provider/health care professional/doctor/ physician prior to use if you are pregnant or breastfeeding.

References

Government of Canada, H. (2019, March 25). Health Canada Ingredient Search. Retrieved September 18, 2020, from http://webprod.hc-sc.gc.ca/nhpid-bdipsn/atReq.do?atid=mushrooms.champignons

IN-DEPTH RESEARCH

Learn why holistic practitioners and biohackers are curious about Lion's Mane as a preventative agent.

By Rhea Mehta, PhD.

HISTORY

Hericium erinaceus (H. erinaceus) is an edible mushroom with distinguished medicinal value that has a long history of usage in Traditional Chinese Medicine and an established process of artificial cultivation in Asia since the late 1980’s. More recently, it has earned scientific attention as a potential source for a variety of therapies including cancer, depression, diabetes, and diseases of the heart and nervous system.

H. erinaceus is referenced by several names, including Yamabushitake in Japanese Medicine, Houtou in Chinese Medicine, or more broadly as Lion’s Mane mushroom. It is considered a saprotroph or weak parasite and naturally occurs on dead wood, and occasionally on the cracks of living hardwood across Asia, Europe and North America. The mature fruiting body of the mushroom can be identified by its fleshy, semi spherical shape and off-white colour, with it gradually changing to yellow-brown with age.

active ingredients

Lion’s mane contains high amounts of protein, carbohydrates and minerals. Additionally, a significantly large number of structurally different bioactive molecules have been identified and isolated from the mushrooms’ fruiting bodies and mycelia. These include hericenones, erinacines, glycoproteins, polysaccharides, steroids, lactones and volatile compounds.

While the majority of medicinal properties of lion’s mane can be attributed to the activity of polysaccharides, and more specifically β-glucans, research on hericenones and erinacines has also revealed beneficial properties, with a focus on the nervous system.  

THERAPEUTIC APPLICATIONS

Research on the therapeutic properties of lion’s mane demonstrates the potential to help prevent, alleviate or treat major diseases, including cancer, depression, diabetes, atherosclerosis and disorders of the nervous system.

In vitro (outside of organism) studies on various cells including lung, liver and spleen have shown the anticancer and immune system modulating properties of polysaccharides in lion’s mane. One study demonstrated the ability of polysaccharides to stimulate the activation of macrophages, which provide defense against tumor cells in the immune system. The likely mechanism was through the increased expression of pro-inflammatory cytokines like tumor necrosis factor (TNF)-α and interleukin (IL)-1β in macrophages. Another study demonstrated the ability of bioactive extracts of lion’s mane to induce apoptosis in human leukemia cells, suggesting a potential therapeutic role of lion’s mane against leukemia.

Of particular interest to researchers today is the neuroprotective and neuroregenerative potential of lion’s mane, given the deep pharmaceutical and medical interests in finding therapies for age-related brain disorders. Both cellular and animal studies have exhibited the promising role of hericenones from fruiting bodies and even erinacines from mycelia in stimulating the production of nerve growth factor (NGF), which is involved in the growth, maintenance, proliferation and survival of the neurons which commonly degenerate during the progression of Alzheimer’s disease (dementia). Further research is needed to replicate current studies and develop a better understanding of the underlying mechanisms of action, in order to determine the role of lion’s mane in the treatment for Alzheimer’s and other diseases of the nervous system.

Polysaccharides in lion’s mane have also demonstrated the potential to improve various types of nervous system injury in cellular and animal studies. One animal study demonstrated the restoration of sensory dysfunction by polysaccharides after peripheral nerve injury. The mechanism likely involved the activation of the critical protein kinase signaling pathways and the restoration of the blood-nerve barrier.

In another study, a double-blind trial was conducted with 50-80 year old Japanese women and men diagnosed with mild cognitive impairment, in order to examine the potential of orally consumed Lion’s mane to improve the condition. Subjects in the Lion’s mane group took four 250mg tablets of Lion’s mane dry powder three times a day for 16 weeks. Cognitive function, as measured using a validated scale, increased with the duration of intake, with no adverse effects observed. This study suggests the potential for Lion’s mane to improve mild cognitive impairment.

Polysaccharides in lion’s mane have also been shown to protect against liver damage in in vitro and in vivo studies, likely through antioxidant effects. In one study, polysaccharides from Lion’s mane protected against liver toxicity by decreasing reactive oxygen species and free radical damage. Studies on diabetic rats also point to the antioxidant capacity of lion’s mane in decreasing serum glucose and lipid profiles, and increasing insulin levels. Cellular studies on the ability of polysaccharides to protect against both heart and kidney injury may also, in part, be attributed to the antioxidant activities of the mushroom. One study looking at the beneficial properties of lion’s mane against cardiovascular complications identified hericenone as the active compound responsible for improving lipid metabolism.

Human studies have also looked at the therapeutic potential of lion’s mane to reduce depression and anxiety. In a randomized, double-blind, placebo-control trial conducted over 4 weeks with 30 female subjects, the group who consumed lion’s mane scored better on epidemiological-based questionnaires on depression, menopause and sleep quality, compared to the placebo group. Whether or not the results point to a NGF stimulating effect or another mechanism remains to be understood.

A number of studies have also shown the antimicrobial activities of bioactive polysaccharides and erinacines against both antibiotic-resistant and non-resistant (susceptible) bacteria. One study demonstrated that polysaccharides in lion’s mane were effective against Helicobacter pylori, which is responsible for many gastric disorders. Another study showed the protective effects of lion’s mane against salmonella-induced liver injury, likely due to the stimulation of the immune system. Studies demonstrating the anti-fatigue and anti-aging activities of polysaccharides in lion’s mane further illuminate the widespread therapeutic potential of this medicinal mushroom.

REMARKS

While the antitumor and immune system modulating activities of lion’s mane are backed by strong evidence in cellular and animal studies, in-depth in vitro, in vivo and clinical studies on the potential mechanisms for protection against neurodegenerative diseases and for the promotion of learning and memory still need to significantly increase. The extensive therapeutic applications discussed, however, do point to the multifunctional health properties of lion’s mane mushrooms, and with negligible adverse effects, which validates the need for deeper scientific and medical attention.

RISKS

Given the lack of research on the effects of lion’s mane mushrooms on higher risk groups, including pregnant and breastfeeding women, and those taking strong medications for chronic diseases reported to be influenced by the medicinal mushroom, it is highly recommended that you consult with your medical doctor or healthcare practitioner before supplementing with the mushroom.

REFLECTION

When I first learned about the brain-boosting effects of lion’s mane, I was inspired to research further and self-experiment. Since then, more studies and products have come out, thereby contributing to widespread attention and curiosity by holistic practitioners and biohackers on the potential of the mushroom as a preventative agent. I continue to use lion’s mane sporadically, either standalone or as part of a brain supplement stack, and what I want to emphasize is that quality matters.

Due to the unregulated nature of this industry, no two products will be alike. Therefore, I urge anyone considering using lion’s mane as a supplement to do your homework and learn about the companies who are using high quality extraction methods, as well as ethical and sustainable practices, to ensure what you are ingesting is going to do you and the planet more good than harm.

REFERENCES

1. Jiang S, Wang S, Sun Y, Zhang Q. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom based pharmaceuticals. Appl. Microbiol. Biotechnol. 2014;98:7661−7670.

2. Chang ST, Miles PG, Mushrooms: Cultivation, Nutritional Value, Medicinal Effect, and Environmental Impact, second edition, CRC Press, Boca Raton, 2004;385–387.

3. Boddy L Wald PM. Creolophus (Hericium) Cirrhatus, Hericium Erinaceus andH. Coralloides in England (English Nature Research Report 492), English Nature, Peterborough, 2003;168–169.

4. Boddy L, Wald PM, Parfitt D, Rogers HJ, Preliminary EcologicalInvestigation of Four Wood-Inhabiting Fungi of Conservation Concern: Oak Polypore Piptoporus Quercinus (=Buglossoporus Pulvinus) and the Tooth Fungi Hericium/Creolophus spp., English Nature, Peterborough, 2004;188–189.

5. Boddy L, Crockatt ME, Ainsworth AM, Ecology of Hericium cirrhatum, H.coralloides and H. erinaceus in the UK, Fungal Ecol. 2011;4:163–173.

6. Weijn A, van den Berg-Somhorst DB, Slootweg JC, et al. Main phenolic compounds of the melanin biosynthesis pathway in bruising-tolerant and bruising-sensitive button mushroom(Agaricus bisporus) strains, J. Agric. Food Chem. 2013;61:8224–8231.

7. Friedman M, Chemistry, nutrition, and health-promoting properties of Hericium erinaceus (Lion’s Mane) mushroom fruiting bodies and mycelia and their bioactive compounds, J. Agric. Food Chem. 2015;63:7108–7123.

8. Wang JC, Hu SH, Su CH, Lee TM. Antitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium spp. Kaohsiung J Med Sci. 2001;17:461–7.

9. Liu C, Gao P, Qian J, Yan W. Immunological study on the antitumor effects of fungus polysaccharides compounds. Wei Sheng Yan Jiu. 2000;29:178–80.

10. Ren L, Perera C, Hemar Y, Antitumor activity of mushroom polysaccharides:a review, Food Funct. 2012;3:1118–1130.

11. Lee JS, Min KM, Cho JY, Hong EK. Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus. J Microbiol Biotechnol. 2009;19:951–9.

12. Kim SP, Kang MY, Choi YH, Kim JH, Nam SH, Friedman M. Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. Food Funct. 2011;2:348–56.

13. Mizuno T, Wasa T, Ito H, Suzuki C, Ukai N, Antitumor-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called yamabushitake or houtou, Biosci.Biotechnol. Biochem. 1992;56:347–348.

14. Zan XY, Cui FJ, Li YH, Yang Y, Wu D et al. Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis, Int. J. Biol. Macromol. 2015;76:242–253.

15. Li KY, He YQ, Chemical studies on polysaccharides from mycelium ofHericium erinaceum (Bull. Ex Fr.) Pers, J. Chin. Mater. Medica. 1999;24:742–744.

16. Yang Y, Zhou CY, Bai YQ, Zhang JS, Isolation, purification and characteristics of polysaccharides from fruit body and mycelia of Hericiumerinaceus, Mycosystema 2001;20:397–402.

17. Lee JS, Cho JY, Hong EK, Study on macrophage activation and structural characteristics of purified polysaccharides from the liquid culture broth ofHericium erinaceus, Carbohydr. Polym. 2009;78:162–168.

18. Yang Y, Qi TH, Hu J, Du J, Wu ZH, Song H, Structural properties of polysaccharides for the mycelium of Hericium caput-medusae, J. Fungal Res. 2013;11:85–88.

19. Ma BJ, Shen JW, Yu HY, Ruan Y, Wu TT, Zhao Z, Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus, Mycology. 2010;1:92–98.

20. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23:367–72.

21. Wong KH, Naidu M, David RP, Abdulla MA, Abdullah N, Kuppusamy UR, et al. Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid Based Complement Alternat Med. 2011;580752.

22. Wong KH, Naidu M, David RP, Bakar R, Sabaratnam V. Neuroregenerative potential of Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review). Int. J. Med. Mushrooms. 2012;14:427−446.

23. Lai, P. L.; Naidu, M.; Sabaratnam, V.; Wong, K. H.; David, R. P.; Kuppusamy, U. R.; Abdullah, N.; Malek, S. N. Neurotrophic properties of the Lion’s Mane medicinal mushroom, Hericium erinaceus (higher Basidiomycetes) from Malaysia. Int. J. Med. Mushrooms. 2013;15:539−554.

24. Kim, M. K.; Choi, W. Y.; Lee, H. Y. Enhancement of the neuroprotective activity of Hericium erinaceus mycelium co-cultivated with Allium sativum extract. Arch. Physiol. Biochem. 2015;121:19−25.

25. Kawagishi, H.; Shimada, A.; Shirai, R.; Okamoto, K.; Ojima, F.; Sakamoto, H.; Ishiguro, Y.; Furukawa, S. Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Lett. 1994;35: 1569−1572.

26. Phan, C. W.; Lee, G. S.; Hong, S. L.; Wong, Y. T.; Brkljaca, R.; Urban, S.; Abd Malek, S. N.; Sabaratnam, V. Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways. Food Funct. 2014;5:3160−3169.

27. Mori, K.; Obara, Y.; Hirota, M.; Azumi, Y.; Kinugasa, S.; Inatomi, S.; Nakahata, N. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol. Pharm. Bull. 2008;31:1727−1732.

28. Wang JC, Hu SH, Wang JT, Chen KS, Chia YC. Hypoglycemic effect of extract of Hericium erinaceus. J Sci Food Agric. 2005;85:641–6.

29. Yang BK, Park JB, Song CH, Hypolipidemic effect of exo-polymer produced in submerged mycelial culture of five different mushrooms, J. Microbiol.Biotechnol. 2002;12:957–961.

30. Yang BK, Park JB, Song CH. Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus. Biosci Biotechnol Biochem. 2003;67:1292–8.

31. Wong KH, Sabaratnam V, Abdullah N, Kuppusamy UR, Naidu M. Effects of cultivation techniques and processing on antimicrobial and antioxidant activities of Hericium erinaceus (Bull.:Fr.) Pers. extracts. Food Technol Biotechnol. 2009;47:47–55.

32. Han ZH, Ye JM, Wang GF. Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides. Int J Biol Macromol. 2013;52:66–71.

33. Zhang Z, Lv G, Pan H, Pandey A, He W, Fan L. Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus grown on tofu whey. Int J Biol Macromol. 2012;51:1140–6.

34. Lee, KF, Chen, JH, Teng, CC, Shen, CH, Hsieh, MC, et al. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int. J.Mol. Sci. 2014;15:15073−15089.

35. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, et al. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010;31:231–7.

36. Dong Q, Jia L. M, Fang JN. A β-D-glucan isolated from the fruiting bodies of Hericium erinaceus and its aqueous conformation. Carbohydr. Res. 2006;341:791−795.

37. Friedman M. Antibiotic-resistant bacteria: prevalence in food and inactivation by food-compatible compounds and plant extracts. J. Agric. Food Chem. 2015;63:3805−3822.

38. Xu CP, Liu WW, Liu FX, Chen SS, Liao FQ, Xu Z, et al. A doubleblind study of effectiveness of Hericium erinaceus pers therapy on chronic atrophic gastritis. A preliminary report. Chin Med J. 1985;98:455–6.

39. Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of Hericium erinaceus and its anti-chronic atrophic gastritis activity, Int. J. Biol.Macromol. 2015;81:656–661.

40. Kim SP, Moon E, Nam SH, Friedman M. Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-induced liver damage and mortality by stimulation of innate immune cells. J. Agric. Food Chem. 2012;60:5590−5596.

41. Shang X, Tan Q, Liu R, Yu K, Li P, Zhao GP. In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion’s Mane mushroom, Hericium erinaceus (higher Basidiomycetes). Int. J. Med. Mushrooms. 2013;15:165−174.

42. Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, et al. Preparation, characterization, and anti-Helicobacter pylori activity of Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr. Polym. 2014;110:231−237.

43. Liu J, Du C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides extracted from Hericium erinaceus. Exp. Ther. Med. 2015;9: 483−487.

About rhea mehta, phd

Rhea Mehta has a PhD in Molecular Toxicology and Nutritional Biochemistry from the University of Toronto and a Bachelor’s in Biomedical Sciences from the University of Waterloo with over 15 scientific publications. Rhea is also a digital health entrepreneur, certified Integrative Health Coach and the founder of Global Smoothie Day.


PRODUCT SPECIFICATIONS

INGREDIENTS

Organically and sustainably grown in climate-controlled greenhouses. Dual extracted and concentrated for a rich source of fungal polysaccharides, hericenones, and erinacines with immunomodulating properties.

INGREDIENTS:  Organic Lion's Mane (Fruiting body and Mycelium), Standardized to 68.6% Polysaccharides, 43.6% Beta-D-Glucans, 0.5% Hericenones, 3.3% Erinacines, 1.9% Polyphenols.

DIRECTIONS

As a dietary supplement, take a 1/4 teaspoon (1 gram) 1 to 3 times a day. Add to juice, smoothies, tea, coffee, or in your favorite recipes. Do not exceed 3 grams per day.

CERTIFICATIONS and LAB reports

Certified USDA Organic, EU Organic, non-GMO Project, ISO 9001, ISO 22000, GMP, Kosher.

Lab Reports

Active Ingredients - Polysaccharides, Beta-Glucans, Erinacines, Herecenones, Polyphenols.

Food Safety - Heavy Metals, Pesticides, Microbiology.

Non-GMO Project

CUSTOMERS LOVE ULTRA PREMIUM LION'S MANE

We think you'll love Ultra Premium Lion's Mane, but don't just take our word for it. Hear why these happy people love their Qi Traditions Lion's Mane.
 
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SEE WHAT THE EXPERT SAYS

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Place your order following these easy steps:

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* Please note that due to COVID-19, there may be delays with shipping carriers and clearing packages through international customs.

CANADA
Shipping is FREE via Canada Post Expedited Parcel and delivery takes 3 to 8 business days.

There is also a Canada Post Xpresspost shipping option and delivery takes 1 to 3 business days. Estimated shipping costs are between CAD$20 to CAD$25, depending on where you live in Canada. Rates are calculated at checkout.

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Shipping is FREE via Canada Post Tracked Packet USA and delivery takes 5 to 8 business days.

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INTERNATIONAL ORDERS
Orders are shipped via Canada Post Tracked Packet International. Estimated shipping costs are between USD$20 to USD$25 and take 6 to 15 business days to deliver, depending on which country you live in.

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WHERE WILL MY ORDER SHIP FROM?

Orders ship from our fulfillment center in Vancouver, BC, CANADA.

WHAT IS YOUR RETURN POLICY?

At Qi Traditions, we take pride in the exceptional quality of our Ultra Premium mushrooms. If for any reason you are not happy with your purchase, please contact us so we can assist with resolving the issue. We will work to meet your needs by either replacing your item or refunding your purchase price for the product in question.

RETURNS
Returns are accepted within 60 days of delivery on unopened items. For health reasons, any opened products are not returnable. To submit your return in a few easy clicks, simply use our self-serve return portal.

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If the product is damaged in any way upon receiving it, please contact us immediately and provide details of the issue. If it is deemed a damaged product, a replacement or refund will be provided.

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Once we receive your return, we will send an email to notify you that we have received your item(s), and let you know if your return has been approved or not. If approved, your refund will be processed to the original method of payment within 5 working days. Shipping costs are non-refundable, except in cases of a shipping error on our part.

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COMPLETE YOUR HEALTH AND VITALITY STACK

Supercharge your immunity by stacking Red Reishi, Cordyceps and Lion's Mane and get an additional 10% discount!

60 grams each of Red Reishi, Cordyceps and Lion's Mane

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120 grams each of Red Reishi, Cordyceps and Lion's Mane

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Ultra Premium Cordyceps
"The Rejuvenator" 60 grams

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Ultra Premium Red Reishi
"The God of Fungi" 60 grams

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THE WAY FORWARD


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